Dopamine D2 Receptors in Substantia Nigra in Schizophrenia

Overview

Journal Brain Res

Specialty Neurology

Date 1984 May 7

PMID 6144367

Citations 10

Authors

R Owen

F Owen

M Poulter

T J Crow

Affiliations

Soon will be listed here.

Abstract

Dopamine D2 receptors were assessed in samples of substantia nigra from controls and schizophrenics. Specific [3H]spiperone binding was significantly increased in both neuroleptic-free and neuroleptic-treated schizophrenics. This supports our previous suggestion that the increase in D2 receptors observed in striatum of schizophrenics is not wholly due to neuroleptic medication.

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