» Articles » PMID: 6138122

Enhancement of Desynchronized Sleep Signs After Pontine Microinjection of the Muscarinic Agonist Bethanechol

Overview
Journal Brain Res
Specialty Neurology
Date 1983 Sep 19
PMID 6138122
Citations 17
Authors
Affiliations
Soon will be listed here.
Abstract

The question of which brainstem neuronal receptors can mediate cholinergic REM sleep induction was investigated by injecting the pure muscarinic agonist bethanechol via glass micropipettes in the pontine tegmentum of cats. The REM sleep enhancement was observed to be equally potent, equally dose-dependent and its appearance equally site-dependent as that previously observed with carbachol, a mixed muscarinic/nicotinic agonist. The results suggest that the pharmacological activation of muscarinic receptors in pontine neurons is sufficient to trigger REM sleep.

Citing Articles

Pedunculopontine-induced cortical decoupling as the neurophysiological locus of dissociation.

Smith D, Terhune D Psychol Rev. 2022; 130(1):183-210.

PMID: 35084921 PMC: 10511303. DOI: 10.1037/rev0000353.


Neuromodulation of Astrocytic K Clearance.

Bellot-Saez A, Stevenson R, Kekesi O, Samokhina E, Ben-Abu Y, Morley J Int J Mol Sci. 2021; 22(5).

PMID: 33802343 PMC: 7959145. DOI: 10.3390/ijms22052520.


REM sleep loss-induced elevated noradrenaline could predispose an individual to psychosomatic disorders: a review focused on proposal for prediction, prevention, and personalized treatment.

Mehta R, Giri S, Mallick B EPMA J. 2020; 11(4):529-549.

PMID: 33240449 PMC: 7680499. DOI: 10.1007/s13167-020-00222-1.


Evaluating the Evidence Surrounding Pontine Cholinergic Involvement in REM Sleep Generation.

Grace K, Horner R Front Neurol. 2015; 6:190.

PMID: 26388832 PMC: 4555043. DOI: 10.3389/fneur.2015.00190.


Endogenous cholinergic input to the pontine REM sleep generator is not required for REM sleep to occur.

Grace K, Vanstone L, Horner R J Neurosci. 2014; 34(43):14198-209.

PMID: 25339734 PMC: 6608391. DOI: 10.1523/JNEUROSCI.0274-14.2014.