Renal Effects of Beta Blockade in Essential Hypertension

Overview

Journal Eur Heart J

Publisher Oxford University Press

Specialty Cardiology & Vascular Diseases

Date 1983 Jul 1

PMID 6137372

Citations 5

Authors

P W de Leeuw

W H Birkenhager

Affiliations

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Abstract

In this paper the effects of beta blockade on renal haemodynamics are reviewed. Although renal blood flow often declines during treatment with beta-blocking drugs, in many cases it is possible to demonstrate relative or absolute vasodilation in the kidney. Renal vasoconstriction seems to be a predominant pattern in patients who do not exhibit a hypotensive response. The mechanism of the changes in renal vascular tone is still not fully understood. The renin-angiotensin system behaves only passively and cannot be held responsible. Evidence is presented that changes in local adrenergic activity may determine the response of the kidney to chronic beta blockade.

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