Effects of Cold Exposure on Blood Pressure, Heart Rate and Forearm Blood Flow in Normotensives During Selective and Non-selective Beta-adrenoceptor Blockade

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1982 Dec 1

PMID 6129886

Citations 4

Authors

H Houben

T Thien

G Wijnands

A vant Laar

Affiliations

Soon will be listed here.

Abstract

Haemodynamic effects of a cold pressor test (foot immersion for 6 min in water at 5 degrees C) without medication and after the non-selective beta-adrenoceptor blocker propranolol and the selective beta-adrenoceptor blocker metoprolol were studied in 17 volunteers. In the control study as well as in the study with the beta-adrenoceptor blockers cold exposure caused comparable changes, namely a blood pressure rise and a reduction of forearm blood flow. The increase in heart rate during cold exposure was clearly and equally reduced by both beta-adrenoceptor blockers. Plasma noradrenaline rose significantly by 47%, plasma adrenaline did not change. It is concluded, that as to this kind of stress, beta 1-selective-adrenoceptor blockade confers no important advantage over non-selective beta-adrenoceptor blockade.

Citing Articles

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The effects of stress on left ventricular ejection fraction.

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Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders.

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Left ventricular function and beta-blockers: does intrinsic sympathomimetic activity have any influence during chronic therapy?.

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