Clinical Pharmacology of a New Beta-adrenoceptor Blocking Drug, Befunolol. Cross-over Comparison with Propranolol on Repeated Administration

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1982 Jan 1

PMID 6129139

Authors

A Ebihara

K Tawara

T Oka

T OFUJI

K Kawahara

Affiliations

Soon will be listed here.

Abstract

Repeated doses of a new beta-adrenoceptor blocking agent, befunolol, were administered orally to adult male volunteers for a cross-over comparison with propranolol. The beta-adrenoceptor blocking activity of befunolol was greater than that of propranolol when assessed by the percentage reduction in exercise-induced tachycardia. The elimination half-life of drug was significantly prolonged on repeated administration of propranolol, but not of befunolol. The percentage reduction in exercise-induced tachycardia was highly correlated with the log plasma level of each drug. Both drugs produced a significant reduction in pre-exercise systolic and diastolic blood pressure, and significant attenuation of exercise-induced rise in systolic blood pressure.

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