Comparison of the Effects of Propranolol, Pindolol, Oxprenolol and Acebutolol on Atrioventricular Conduction in Unanaesthetized Dogs

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1982 Jan 1

PMID 6125165

Authors

J P Kantelip

P DUCHENE-MARULLAZ

A Eschalier

Affiliations

Soon will be listed here.

Abstract

1 Atrio-ventricular conduction (AVC) in the unanaesthetized dog (17 animals) was studied using atrial pacing at progressively increasing frequencies applied via electrodes implanted in the right atrium. In animals habituated to the experimental conditions, beta-adrenoceptor blocking drugs devoid of intrinsic sympathomimetic activity (ISA) modified neither heart-rate (HR) nor AVC, though 4 mg/kg i.v. propranolol transiently raised HR and facilitated AVC. Due to their ISA, pindolol and oxprenolol raised HR and facilitated AVC at high doses. 2 Thus, when not under anaesthesia, the resting dog, in contrast to man, possesses no tonic adrenergic influence which might be suppressed by beta-adrenoceptor blockings drugs. 3 After atropine or pentobarbitone, which considerably increased HR, beta-adrenoceptor blocking effects became clearly visible, and the hitherto reported depressant effects on HR and AVC were observed. However, the ISA of oxprenolol, and especially of pindolol, can partly or completely mask their beta-adrenoceptor blocking action at high doses under these experimental conditions.

References

Mason J, Winkle R, Meffin P, Harrison D . Electrophysiological effects of acebutolol. Br Heart J. 1978; 40(1):35-40. PMC: 481971. DOI: 10.1136/hrt.40.1.35. View

DUCHENE MARULLAZ P, ARNOULD P, BOULANGE M, SCHAFF G . [POSITIVE DROMOTROPIC TONUS PATHWAYS IN THE DOG]. C R Seances Soc Biol Fil. 1963; 157:2192-3. View

Jaillon P, Heckle J, Weissenburger J, Cheymol G . Cardiac electrophysiologic properties of dl-propranolol, d-propranolol, l-propranolol and dl-pindolol in anesthetized dogs. J Pharmacol Exp Ther. 1980; 212(2):347-53. View

Cuthbert M, Owusu-Ankomah K . Effect of M & B 17803A, a new -adrenoceptor blocking agent, on the cardiovascular responses to tilting and to isoprenaline in man. Br J Pharmacol. 1971; 43(3):639-48. PMC: 1665788. DOI: 10.1111/j.1476-5381.1971.tb07193.x. View

Bergamaschi M, Shanks R, Caravaggi A, MANDELLI V . A comparison of the cardiovascular actions of four adrenergic -receptor blocking agents in resting, conscious dogs. Am Heart J. 1971; 82(3):338-51. DOI: 10.1016/0002-8703(71)90300-0. View

DUCHENE-MARULLAZ P, SCHAFF G, Lautier F, Condat M . [Data furnished on the extrinsic innervation of the canine heart by an agent blocking beta adrenergic receptors]. C R Seances Soc Biol Fil. 1967; 161(2):306-9. View

Giudicelli J, Lhoste F, BOISSIER J . Beta-adrenergic blockade and atrio--ventricular conduction impairment. Eur J Pharmacol. 1975; 31(2):216-25. DOI: 10.1016/0014-2999(75)90042-4. View

PRIOLA D . Effects of beta receptor stimulation and blockade on A-V nodal and bundle branch conduction in the canine heart. Am J Cardiol. 1973; 31(1):35-40. DOI: 10.1016/0002-9149(73)90807-2. View

Fitzgerald J, Wale J . The effects of -blocking drugs on atrioventricular conduction and contractility. Cardiology. 1971; 56(1):338-43. DOI: 10.1159/000169380. View

10.

Giudicelli J, Schmitt H, BOISSIER J . Studies on dl-4-(2-hydroxy-3-isopropylaminopropoxy)-indole A/Giudicelli JF, Schmitt H, Boissier JR: Studies on dl-4-(2-hydroxy-3-isopropylaminopropoxy)-indole (LB 46), a new potent beta adrenergic blocking drug. J Pharmacol Exp Ther. 1969; 168(1):116-26. View

11.

Singh B . Clinical aspects of the anti-arrhythmic actions of beta-receptor blocking drugs. 2. Clinical pharmacology. N Z Med J. 1973; 78(505):529-35. View

12.

Jaillon P, Heckle J, Weissenburger J, Cheymol G . Comparative dromotropic activity of timolol and propranolol in anesthetized dogs. Eur J Pharmacol. 1978; 47(2):129-39. DOI: 10.1016/0014-2999(78)90384-9. View

13.

Buckingham R, Hamilton T, Robson D . Diminishing hypotensive effect of increasing doses of pindolol in DOCA/saline hypertensive rats. Br J Pharmacol. 1978; 62(3):362-3. PMC: 1668179. DOI: 10.1111/j.1476-5381.1978.tb08469.x. View

14.

Seides S, Josephson M, Batsford W, Weisfogel G, Lau S, DAMATO A . The electrophysiology of propranolol in man. Am Heart J. 1974; 88(6):733-41. DOI: 10.1016/0002-8703(74)90283-x. View

15.

Touboul P, Huerta F, Porte J, Delahaye J . [Electrophysiologic properties of acebutolol in man]. Therapie. 1975; 30(3):417-27. View

16.

Barrett A, Carter J . Comparative chronotropic activity of beta-adrenoceptive antagonists. Br J Pharmacol. 1970; 40(3):373-81. PMC: 1703170. DOI: 10.1111/j.1476-5381.1970.tb10619.x. View

17.

Manders W, Vatner S . Effects of sodium pentobarbital anesthesia on left ventricular function and distribution of cardiac output in dogs, with particular reference to the mechanism for tachycardia. Circ Res. 1976; 39(4):512-7. DOI: 10.1161/01.res.39.4.512. View

18.

Di Biase M, Brindicci G, Rizzon P . Effects of prindolol on impulse formation and conduction in man. J Electrocardiol. 1977; 10(1):45-50. DOI: 10.1016/s0022-0736(77)80030-7. View

19.

NASH C, Davis F, WOODBURY R . Cardiovascular effects of anesthetic doses of pentobarbital sodium. Am J Physiol. 1956; 185(1):107-12. DOI: 10.1152/ajplegacy.1956.185.1.107. View

20.

Coltart D, Gibson D, SHAND D . Plasma propranolol levels associated with suppression of ventricular ectopic beats. Br Med J. 1971; 1(5747):490-1. PMC: 1795199. DOI: 10.1136/bmj.1.5747.490. View