Effect of Dietary Lipid on Locomotor Activity and Response to Psychomotor Stimulants

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1982 Jan 1

PMID 6124992

Citations 5

Authors

D E Brenneman

C O RUTLEDGE

Affiliations

Soon will be listed here.

Abstract

Spontaneous locomotor activity was investigated in developing rats fed diets rich in either saturated fat (coconut oil) or polyunsaturated fat (sunflower oil). The locomotor activity response to amphetamine, methylphenidate, and atropine in the dietary groups was also measured. Rats from dams fed sunflower oil had a late developing (20 days of age) increase in basal locomotor activity when compared to rats from dams fed coconut oil and the standard laboratory diet. The locomotor activity response to d-amphetamine administered IP to 30-day-old animals was potentiated in rats exposed to coconut oil compared to the other two groups. A dose-response analysis of the effect of methylphenidate revealed no differences among the dietary groups. A low dose of atropine (2 mg/kg) decreased 1 h locomotor activity 40% below basal level in rats fed sunflower oil but increased locomotor activity 90% over basal activity in rats fed coconut oil. These results indicate that dietary lipid can have a marked effect on basal locomotor activity as well as on the response to stimulant drugs.

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References

BORGMAN R, Bursey R, Caffrey B . Influence of maternal dietary fat upon rat pups. Am J Vet Res. 1975; 36(6):799-805. View

Kellogg C, Lundborg P . Ontogenic variations in responses to L-DOPA and monoamine receptor-stimulating agents. Psychopharmacologia. 1972; 23(2):187-200. DOI: 10.1007/BF00401194. View

Svensson T, THIEME G . An investigation of a new instrument to measure motor activity of small animals. Psychopharmacologia. 1969; 14(2):157-63. DOI: 10.1007/BF00403689. View

Pradhan S, Roth T . Comparative behavioral effects of several anticholinergic agents in rats. Psychopharmacologia. 1968; 12(4):358-66. DOI: 10.1007/BF00401415. View

Chiueh C, Moore K . Blockade by reserpine of methylphenidate-induced release of brain dopamine. J Pharmacol Exp Ther. 1975; 193(2):559-63. View

Bernsohn J, Spitz F . Linoleic- and linolenic acid dependency of some brain membrane-bound enzymes after lipid deprivation in rats. Biochem Biophys Res Commun. 1974; 57(1):293-8. DOI: 10.1016/s0006-291x(74)80389-x. View

Hostmark A, RASMUSSEN E, ASKEVOLD R . Dissociation between dietary effects on plasma lipid concentration and on plasma lipoprotein distribution in selected rats. J Nutr. 1978; 108(11):1823-9. DOI: 10.1093/jn/108.11.1823. View

Pilecki R, Samochowiec L, Szyszka K . The influence of atherogenic diet and "essential" phospholipids upon the contents of noradrenaline and dopamine in the brain of rats and their exploratory activity. Atherosclerosis. 1975; 22(3):401-10. DOI: 10.1016/0021-9150(75)90020-9. View

Campbell B, Lytle L, Fibiger H . Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat. Science. 1969; 166(3905):635-7. DOI: 10.1126/science.166.3905.635. View

10.

Kuczenski R, Segal D . Differential effects of D- and L-amphetamine and methylphenidate on rat striatal dopamine biosynthesis. Eur J Pharmacol. 1975; 30(2):244-51. DOI: 10.1016/0014-2999(75)90106-5. View

11.

Tyler T, Tessel R . Amphetamine's locomotor-stimulant and noreprinephrine-releasing effects: evidence for selective antagonism by nisoxetine. Psychopharmacology (Berl). 1979; 64(3):291-6. DOI: 10.1007/BF00427512. View

12.

RATHBONE L . The effect of diet on the fatty acid compositions of serum, brain, brain mitochondria and myelin in the rat. Biochem J. 1965; 97(3):620-8. PMC: 1264738. DOI: 10.1042/bj0970620. View

13.

Campbell B, Mabry P . The role of catecholamines in behavioral arousal during ontogenesis. Psychopharmacologia. 1973; 31(3):253-64. DOI: 10.1007/BF00422515. View

14.

Brenneman D, RUTLEDGE C . Alteration of catecholamine uptake in cerebral cortex from rats fed a saturated fat diet. Brain Res. 1979; 179(2):295-304. DOI: 10.1016/0006-8993(79)90445-1. View

15.

Rech R, Borys H, Moore K . Alterations in behavior and brain catecholamine levels in rats treated with alpha-methyltyrosine. J Pharmacol Exp Ther. 1966; 153(3):412-9. View

16.

Aquilonius S, Lundholm B, Winbladh B . Effects of some anticholinergic drugs on cortical acetylcholine release and motor activity in rats. Eur J Pharmacol. 1972; 20(2):224-30. DOI: 10.1016/0014-2999(72)90152-5. View

17.

Thornburg J, Moore K . Postnatal development of benztropine-induced locomotor stimulation: evidence for an anticholinergic mechanism of action. Res Commun Chem Pathol Pharmacol. 1973; 6(1):313-20. View

18.

Bartholow R, Eiden L, Ruth J, Grunewald G, Siebert J, RUTLEDGE C . Conformationally defined adrenergic agents. II. The effect of endo- and exo-2-aminobenzobicyclo-[2.2.2] octene, conformationally defined amphetamine analogs, on the uptake and release of central catecholamines. J Pharmacol Exp Ther. 1977; 202(3):532-43. View

19.

Awad A, Spector A . Modification of the fatty acid composition of Ehrlich ascites tumor cell plasma membranes. Biochim Biophys Acta. 1976; 426(4):723-31. DOI: 10.1016/0005-2736(76)90137-1. View