Alterations in Norepinephrine, Serotonin, C-AMP, and Transsynaptic Induction of Tyrosine Hydroxylase After Spinal Cord Transection in the Rat

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1981 Nov 1

PMID 6123957

Authors

N E NAFTCHI

A K Kirschner

M Demeny

A T Viau

Affiliations

Soon will be listed here.

Abstract

Tyrosine hydroxylase (TH) activity and the concentrations of norepinephrine (NE), serotonin (5-HT), and cyclic adenosine 3',5'-monophosphate (c-AMP) were measured in the heart, adrenals, and brain stem of paraplegic rats. Following spinal cord transection NE concentration in the heart dropped to 30% within 24 hours and that of 5-HT decreased to 60% of control. Tyrosine hydroxylase activity in the adrenals reached a peak at five days and was still twice that of sham-operated controls thirty days later. Five days following transection the TH activity and c-AMP levels in the brain stem were elevated while NE concentration remained low. At seven days, however, NE and 5-HT levels were higher than in controls while TH activity and c-AMP concentration dropped to control levels. The increase in TH activity in the brain stem may be due to curtailed end-product feedback inhibition and to reduced receptor activation. The sustained induction of the adrenal TH is probably a consequence of a continual stimulation of splanchnic nerves.

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