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Raised Cytomegalovirus-antibody Level in Cerebrospinal Fluid of Schizophrenic Patients

Overview
Journal Lancet
Publisher Elsevier
Specialty General Medicine
Date 1980 Oct 11
PMID 6107453
Citations 21
Authors
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Abstract

The serum and cerebrospinal fluid (CSF) of 60 schizophrenic patients and 26 controls were analysed for viral antibody against cytomegalovirus (CMV), vaccinia virus, herpes simplex virus type 1 (HSV), and type A influenza virus. A CSF/serum antibody ratio more than 2 standard deviations above the mean of the controls suggested local antibody production in the central nervous system. 68% of the patients had an increased CSF/serum antibody ratio for CMV antibody, 14% for vaccinia antibody, 4% for HSV antibody, and 15% for influenza virus antibody.

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