Treatment of Acute Respiratory Failure with Low-frequency Positive-pressure Ventilation and Extracorporeal Removal of CO2

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1980 Aug 9

PMID 6105441

Citations 58

Authors

L Gattinoni

A AGOSTONI

A Pesenti

A Pelizzola

G P Rossi

M Langer

S Vesconi

L Uziel

U Fox

F Longoni

T Kolobow

G Damia

Affiliations

Soon will be listed here.

Abstract

Terminal respiratory failure was reversed in three patients with a combination of extra-corporeal CO2 removal through a membrane lung and oxygen diffusion into the diseased lungs between mechanical breaths induced at a frequency of 2-3/min. The technique seems to prevent the pulmonary barotrauma and extrapulmonary derangements caused by conventional mechanical ventilation.

Citing Articles

Thank you, Professor Gattinoni†, and have a good trip to eternity!.

Bugedo G, Nin N, Estenssoro E, Machado F Crit Care Sci. 2025; 37:e20250002.

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Forty years on, why are we still publishing extracorporeal carbon dioxide removal feasibility studies?.

Cove M, Combes A, P Hilty M Crit Care. 2025; 29(1):35.

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Lung Imaging and Artificial Intelligence in ARDS.

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Gas volume corrections in intensive care unit: needed or pointless?.

DAlbo R, Romitti F, Camporota L, Moerer O, Busana M, Gattinoni L J Appl Physiol (1985). 2023; 135(2):334-342.

PMID: 37345856 PMC: 10390049. DOI: 10.1152/japplphysiol.00225.2023.

High- versus Low-Flow Extracorporeal Respiratory Support in Experimental Hypoxemic Acute Lung Injury.

Brusatori S, Zinnato C, Busana M, Romitti F, Gattarello S, Palumbo M Am J Respir Crit Care Med. 2023; 207(9):1183-1193.

PMID: 36848321 PMC: 10161753. DOI: 10.1164/rccm.202212-2194OC.