Presence of AVT-, Alpha-MSH-, LHRH- and Somatostatin-like Compounds in the Rat Pineal Gland and Their Relationship with the UMO5R Pineal Fraction. An Immunocytochemical Study

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1980 Jan 1

PMID 6104539

Citations 16

Authors

P Pevet

I EBELS

D F Swaab

M T Mud

A Arimura

Affiliations

Soon will be listed here.

Abstract

Using antibodies against AVT, alpha-MSH, LHRH and somatostatin, immunoreactive cells were detected in the rat pineal gland. All of these antibodies stain the same cells, which also react immunocytochemically when an antibody against the UMO5R sheep pineal fraction, a fraction that presents antigonadotropic properties in vivo, is used. Relatively more immunoreactive cells are present in the pineals of young rats than in the pineals of adult animals. Comparison of the results obtained with different potent antibodies against each of the peptides, and a study of the staining properties of the antibodies in the pineal after solid phase absorption to different peptides or to different sheep pineal fractions, led to the proposal that the immunoreactivity found in the rat pineal is not due to the presence of AVT, alpha-MSH, LHRH or somatostatin, but to a cross-reaction of each of these antibodies with (an) unidentified compound(s). This compound is synthetized in the pineal gland, as was demonstrated using cultured pineals. The UMO5R and the Prot. 4 fractions of the sheep pineal seem to be chemically related to this unknown compound, the possible endocrine nature of which is discussed.

Citing Articles

The pineal gland of the mole (Talpa europaea L.).

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The vasotocin-like biological activity present in the bovine pineal is due to a compound different from vasotocin.

Pevet P, Neacsu C, Holder F, REINHARZ A, Dogterom J, Buijs R J Neural Transm. 1981; 51(3-4):295-302.

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Oxytocin- and vasopressin-immunoreactive nerve fibers in the pineal gland of the hedgehog, Erinaceus europaeus L.

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Pools of serotonin in the pineal gland of the mouse: the mammalian pinealocyte as a component of the diffuse neuroendocrine system.

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Comparison of some peptidic and proteic ovine pineal fractions with a bovine pineal E5 fraction.

Noteborn H, EBELS I, Pevet P, Reinharz A, Neacsu C, Salemink C J Neural Transm. 1982; 55(1):27-44.

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