Inhibition of Gastric Secretion in Man with a New H2-receptor Antagonist, Ranitidine

Overview

Journal Scand J Gastroenterol

Publisher Informa Healthcare

Specialty Gastroenterology

Date 1980 Jan 1

PMID 6104355

Citations 9

Authors

K Kett

E Aadland

A Berstad

Affiliations

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Abstract

Inhibition of pentagastrin-evoked gastric secretion of acid and pepsin by cimetidine and a new H2-receptor antagonist, ranitidine, was compared in nine healthy young subjects. On separate days cimetidine or ranitidine was administered by continuous intravenous infusions in graded doses. The results demonstrated that the inhibitory effect of ranitidine was 6 and 7.3 times as potent as cimetidine on a weight and a molar basis, respectively.

Citing Articles

Effect of H2-receptor blockade by ranitidine on ulcer healing and gastric acid secretion in patients with gastric and duodenal ulcers.

Forssell H, Koch G Eur J Clin Pharmacol. 1983; 25(2):195-8.

PMID: 6313376 DOI: 10.1007/BF00543790.

Gastro-oesophageal function in normal subjects after oral administration of ranitidine.

Wallin L, Madsen T, Boesby S Gut. 1983; 24(2):154-7.

PMID: 6133814 PMC: 1420169. DOI: 10.1136/gut.24.2.154.

Ranitidine: a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases.

Brogden R, Carmine A, Heel R, Speight T, Avery G Drugs. 1982; 24(4):267-303.

PMID: 6128216 DOI: 10.2165/00003495-198224040-00002.

Comparative trial of the effect of ranitidine and cimetidine on gastric secretion in fasting patients at induction of anaesthesia.

Durrant J, Strunin L Can Anaesth Soc J. 1982; 29(5):446-51.

PMID: 6127150 DOI: 10.1007/BF03009407.

Ranitidine and duodenal ulceration: a short-term and maintenance study.

Sheers R, McKay J, Hughes S J R Soc Med. 1982; 75(5):323-6.

PMID: 6122738 PMC: 1437798. DOI: 10.1177/014107688207500506.