Failure of Autoregulation and Intraventricular Haemorrhage in Preterm Infants

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1980 Apr 26

PMID 6103257

Citations 22

Authors

D W Milligan

Affiliations

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Abstract

Changes in mean arterial blood-pressure produced in five sick newborn infants by transfusion or exchange of blood products were accompanied by striking increases in cerebral blood-flow. These increases imply a failure of autoregulation. Four of the infants had a fatal intraventricular haemorrhage within 12 h of the observed change in flow. This suggests that the increase in flow precipitated the haemorrhage.

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