Decrease in the Number of High-affinity Opiate Binding Sites During the Aging Process in Mytilus Edulis (Bivalvia)

Overview

Journal Cell Mol Neurobiol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Neurology

Date 1981 Dec 1

PMID 6101081

Authors

G B Stefano

Affiliations

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Abstract

As Mytilus edulis (Bivalvia) ages, the number of stereospecific opiate binding sites in the visceral ganglia significantly decreases. The number of high-affinity etorphine sites decreased by 30%; the number of naloxone sites decreased by 23%. The affinity of the ligands did not vary with age. In addition, the augmentation by opioids of dopamine levels in the visceral ganglia was less in older animals and was accompanied by a reduced sensitivity of the ganglia to etorphine and DAMA (D-Ala2,Met5-enkephalin-amide).

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Alterations in high-affinity binding characteristics and levels of opioids in invertebrate ganglia during aging: evidence for an opioid compensatory mechanism.

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References

Stefano G, Catapane E . Enkephalins increase dopamine levels in the CNS of a marine mollusc. Life Sci. 1979; 24(17):1617-21. DOI: 10.1016/0024-3205(79)90024-9. View

Kream R, Zukin R, Stefano G . Demonstration of two classes of opiate binding sites in the nervous tissue of the marine mollusc Mytilus edulis. Positive homotropic cooperativity of lower affinity binding sites. J Biol Chem. 1980; 255(19):9218-24. View

Kream R, Zukin R . Binding characteristics of a potent enkephalin analog. Biochem Biophys Res Commun. 1979; 90(1):99-109. DOI: 10.1016/0006-291x(79)91595-x. View

Shih J, Young H . The alteration of serotonin binding sites in aged human brain. Life Sci. 1978; 23(14):1441-8. DOI: 10.1016/0024-3205(78)90125-x. View

Finch C . Age-related changes in brain catecholamines: a synopsis of findings in C57BL/6J mice and other rodent models. Adv Exp Med Biol. 1978; 113:15-39. DOI: 10.1007/978-1-4684-8893-7_2. View

Stefano G, Kream R, Zukin R . Demonstration of stereospecific opiate binding in the nervous tissue of the marine mollusc Mytilus edulis. Brain Res. 1980; 181(2):440-5. DOI: 10.1016/0006-8993(80)90626-5. View

Severson J, Finch C . Reduced dopaminergic binding during aging in the rodent striatum. Brain Res. 1980; 192(1):147-62. DOI: 10.1016/0006-8993(80)91015-x. View

MAKMAN M, Ahn H, Thal L, Sharpless N, Dvorkin B, Horowitz S . Evidence for selective loss of brain dopamine- and histamine-stimulated adenylate cyclase activities in rabbits with aging. Brain Res. 1980; 192(1):177-83. DOI: 10.1016/0006-8993(80)91017-3. View

LOWRY O, ROSEBROUGH N, FARR A, RANDALL R . Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1):265-75. View

10.

Govoni S, Spano P, Trabucchi M . [3H]Haloperidol and [3H]spiroperidol binding in rat striatum during ageing. J Pharm Pharmacol. 1978; 30(7):448-9. DOI: 10.1111/j.2042-7158.1978.tb13284.x. View

11.

McGeer P, McGeer E . Aging and neurotransmitter systems. Adv Exp Med Biol. 1978; 113:41-57. DOI: 10.1007/978-1-4684-8893-7_3. View

12.

Messing R, Vasquez B, Spiehler V, Martinez Jr J, Jensen R, Rigter H . 3H-Dihydromorphine binding in brain regions of young and aged rats. Life Sci. 1980; 26(12):921-7. DOI: 10.1016/0024-3205(80)90112-5. View

13.

Thal L, Horowitz S, Dvorkin B, MAKMAN M . Evidence for loss of brain [3H]spiroperidil and [3H]ADTN binding sites in rabbit brain with aging. Brain Res. 1980; 192(1):185-94. DOI: 10.1016/0006-8993(80)91018-5. View

14.

Zukin R, Kream R . Chemical crosslinking of a solubilized enkephalin macromolecular complex. Proc Natl Acad Sci U S A. 1979; 76(4):1593-7. PMC: 383436. DOI: 10.1073/pnas.76.4.1593. View

15.

Stefano G, Aiello E . Histofluorescent localization of serotonin and dopamine in the nervous system and gill of Mytilus edulis (Bivalvia). Biol Bull. 1975; 148(1):141-56. DOI: 10.2307/1540655. View