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Enalapril in Heart Failure

Overview
Journal Br J Clin Pharmacol
Specialty Pharmacology
Date 1984 Jan 1
PMID 6099733
Citations 3
Authors
M G Nicholls
H Ikram
E A Espiner
M W Webster
M A Fitzpatrick
Affiliations
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Abstract

Serum MK-422 and plasma angiotensin converting enzyme activity were measured during the introduction of enalapril therapy in eight patients with heart failure. In a second study of 16 patients, we recorded exercise tolerance, clinical status and haemodynamics before and after 12 weeks of placebo or enalapril treatment. Increasing doses of enalapril gave step-wise increments in serum MK-422. Plasma converting enzyme activity remained low for at least 24 h after each dose of enalapril (5, 10 and 20 mg). Compared to placebo patients (n = 8), those receiving enalapril (n = 8) tended to improve their exercise performance and clinical status, and showed a fall in right heart pressures after 12 weeks of treatment.

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