The Diagnostic Significance of a Positive Direct Antiglobulin Test in Anemic Cats

Overview

Journal Can J Comp Med

Specialty Veterinary Medicine

Date 1984 Oct 1

PMID 6095976

Citations 5

Authors

J K Dunn

G P Searcy

V M Hirsch

Affiliations

Soon will be listed here.

Abstract

The preparation of a feline Coombs serum (rabbit antifeline gamma globulin) is described. The direct antiglobulin test using this serum was performed on 20 anemic and 20 healthy control cats. Red cell membrane antibodies were detected in cats with feline leukemia virus infection and in others with inflammatory and neoplastic diseases. A low titre of cold agglutinating antibody was present in a high proportion of the control cats. Positive direct antiglobulin tests were noted in cats without overt hemolytic disease. It was concluded that the direct antiglobulin test in anemic cats has certain diagnostic limitations. A positive reaction should be interpreted cautiously especially when there is no clinical or laboratory evidence to support a diagnosis of autoimmune hemolytic anemia.

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