Electron Microscopic Examination of Congenital Cytomegalovirus Hepatitis

Overview

Journal Virchows Arch A Pathol Anat Histopathol

Specialty Anatomy & Histology

Date 1984 Jan 1

PMID 6095523

Authors

M Balazs

Affiliations

Soon will be listed here.

Abstract

The electron microscopic features of cytomegalovirus hepatitis in the liver biopsy of a three-week-old infant were studied. The liver cells did not contain virus, but severe alterations similar to virus hepatitis were observed. In the bile duct cells, nuclear and cytoplasmic virus inclusions were demonstrated. In the nuclear inclusions virus particles of various degrees of maturity were embedded in dense granular material. The cytoplasm of the infected cells contained vacuoles with mature viruses. The Golgi zone seemed to play an important role in vacuole formation. In another type of infected cell, viruses were lying free in the cytoplasm and passed into the lumen of the bile ducts. It is concluded that viruses are eliminimated by the bile. Based on this electron microscopical observations, the examination of duodenal fluid is recommended as a new diagnostic procedure for demonstrating viruses.

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