Slow Virus Visna: Reproduction in Vitro of Virus from Extrachromosomal DNA

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1984 Nov 1

PMID 6095275

Citations 24

Authors

J D Harris

H Blum

J Scott

B Traynor

P Ventura

A Haase

Affiliations

Soon will be listed here.

Abstract

Under permissive conditions of growth in tissue culture, the retrovirus visna multiples over the course of a few days to high titer and kills the host cell. We show that in this lytic life cycle, viral DNA is tightly associated with, but not covalently linked to, chromosomal DNA. This finding provides explanations for a number of the unusual properties of the lentivirus subfamily of retroviruses, and suggests potential mechanisms for the block in virus gene expression in vivo responsible for the slow infection in nature.

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