Alpha 2 and Beta-adrenoceptor Agonists Modulate [3H]dopamine Release from Rat Nucleus Accumbens Slices: Implications for Research into Depression

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1984 Sep 1

PMID 6095129

Citations 16

Authors

B Nurse

V A Russell

J J Taljaard

Affiliations

Soon will be listed here.

Abstract

The modulatory effects of noradrenergic agonists on the 25 mM K+-induced release of [3H]dopamine (3H-DA) from rat brain nucleus accumbens slices was investigated, using a superfusion technique. The K+-induced release of 3H-DA was Ca2+ dependent, significantly enhanced (25-32%; p less than 0.02) by the beta-adrenoceptor agonist isoproterenol (10 microM), and significantly decreased (13-25%; p less than 0.05) by the alpha 2-adrenoceptor agonist clonidine (10 microM). At these concentrations neither drug affected basal release of 3H-DA. Clonidine (100 microM) increased the basal release of 3H-DA, while decreasing the K+-induced release by 19% (p less than 0.01). The inclusion of desipramine in the incubation medium, to prevent accumulation of 3H-DA into noradrenergic neurons, did not alter the inhibitory effect of clonidine (10 microM) on 3H-DA release. This study provides direct evidence that noradrenergic neurons can modulate dopaminergic neurotransmission in the mesolimbic system.

Citing Articles

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