The Neu Oncogene: an Erb-B-related Gene Encoding a 185,000-Mr Tumour Antigen

Overview

Journal Nature

Specialty Science

Date 1984 Dec 6

PMID 6095109

Citations 291

Authors

A L Schechter

D F Stern

L Vaidyanathan

S J Decker

J A Drebin

M I Greene

R A Weinberg

Affiliations

Soon will be listed here.

Abstract

A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.

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