CFS Oligoclonal Bands in MS and Other Neurological Diseases Detected by Agarose Isoelectric Focusing and Electrophoresis

Overview

Journal Ital J Neurol Sci

Specialty Neurology

Date 1984 Sep 1

PMID 6094393

Citations 1

Authors

D Cerrato

A Salmaggi

C Ariano

L La Mantia

A Nespolo

Affiliations

Soon will be listed here.

Abstract

Agarose gel isoelectric focusing (IEF) and electrophoresis (EF) were compared for detection of CSF oligoclonal bands in multiple sclerosis (MS) and other neurological diseases. The CSF IgG/albumin ratio, the IgG-Index and the IgG synthesis per day in the CNS were also considered. IEF was highly sensitive, revealing oligoclonal bands in 100% of CSF from 40 clinically definite MS, while EF had a sensitivity of 70%. In 90 patients with other neurological diseases, IEF revealed oligoclonal bands in 25.5%, EF in 11.1%. The IgG-index was the most sensitive of the quantitative parameters.

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