Alpha 2.0
Login Register
» Articles » PMID: 6093542

Growth-hormone-releasing Factor Immunoreactivity in Human Endocrine Tumors

Overview
Journal Am J Pathol
Publisher Elsevier
Specialty Pathology
Date 1984 Nov 1
PMID 6093542
Citations 4
Authors
D G Bostwick
R Quan
A R Hoffman
R J Webber
J K Chang
K G Bensch
Affiliations
Soon will be listed here.
Abstract

Seventy-three human tumors and adjacent nonneoplastic tissues were analyzed immunohistochemically for the presence of growth-hormone-releasing factor (GRF). Four of 9 pancreatic endocrine tumors, 2 of 3 appendiceal carcinoids, and 1 of 5 cecal carcinoids were immunoreactive for GRF. One of the GRF-containing pancreatic tumors was associated with acromegaly. Histologically, the growth patterns of these tumors were variable, and the distribution of immunoreactive cells was patchy and irregular. There were no normal cells that contained GRF. These results indicate that GRF production by human tumors is more common than previously thought, although clinical acromegaly may not be apparent in patients who harbor such neoplasms.

Citing Articles

The Adult Pancreas in Trauma and Disease.

Walker A Acad Forensic Pathol. 2019; 8(2):192-218.

PMID: 31240039 PMC: 6490126. DOI: 10.1177/1925362118781612.

Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors.

Kloppel G, Rindi G, Anlauf M, Perren A, Komminoth P Virchows Arch. 2007; 451 Suppl 1:S9-27.

PMID: 17684761 DOI: 10.1007/s00428-007-0461-0.

Ectopic secretion of growth hormone-releasing hormone in man.

Losa M, Schopohl J, von Werder K J Endocrinol Invest. 1993; 16(1):69-81.

PMID: 8445159 DOI: 10.1007/BF03345835.

Morphology of a GHRH producing pancreatic islet cell tumour causing acromegaly.

Saeger W, Schulte H, Kloppel G Virchows Arch A Pathol Anat Histopathol. 1986; 409(4):547-54.

PMID: 3016979 DOI: 10.1007/BF00705425.

References
1.
Leveston S, McKeel Jr D, Buckley P, Deschryver K, Greider M, Jaffe B . Acromegaly and Cushing's syndrome associated with a foregut carcinoid tumor. J Clin Endocrinol Metab. 1981; 53(4):682-9. DOI: 10.1210/jcem-53-4-682. View
2.
Guillemin R, BRAZEAU P, Bohlen P, Esch F, Ling N, Wehrenberg W . Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science. 1982; 218(4572):585-7. DOI: 10.1126/science.6812220. View
3.
Rivier J, Spiess J, Thorner M, Vale W . Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature. 1982; 300(5889):276-8. DOI: 10.1038/300276a0. View
4.
Bloch B, BRAZEAU P, Ling N, Bohlen P, Esch F, Wehrenberg W . Immunohistochemical detection of growth hormone-releasing factor in brain. Nature. 1983; 301(5901):607-8. DOI: 10.1038/301607a0. View
5.
Yang K, Ulich T, Cheng L, Lewin K . The neuroendocrine products of intestinal carcinoids. An immunoperoxidase study of 35 carcinoid tumors stained for serotonin and eight polypeptide hormones. Cancer. 1983; 51(10):1918-26. DOI: 10.1002/1097-0142(19830515)51:10<1918::aid-cncr2820511027>3.0.co;2-y. View