Effects of Systemically Administered Cholecystokinin-octapeptide on Local Cerebral Metabolism

The effects of systemically administered cholecystokinin-octapeptide on local cerebral glucose utilization in rats were studied by means of the 2-[14C]deoxyglucose method. Decreases in cerebral glucose utilization were observed in discrete regions of the cerebral cortex, mesencephalon, and brainstem, including the lateral habenula, ventral tegmental area, substantia nigra pars compacta, and the nucleus of the solitary tract. These data demonstrate changes in metabolic activity in specific cerebral regions following systemic cholecystokinin administration.