Somatostatin Therapy of Acute Experimental Pancreatitis

Overview

Journal Gut

Specialty Gastroenterology

Date 1977 Sep 1

PMID 604191

Citations 20

Authors

P G Lankisch

H Koop

K WINCKLER

U R Folsch

W Creutzfeldt

Affiliations

Soon will be listed here.

Abstract

Because somatostatin (SRIF) reduces exocrine pancreatic secretion, its effect on acute pancreatitis was investigated in rats. Linear SRIF reduced serum amylase and lipase but had no effect on pancreatic necrosis, oedema, leucocyte infiltration, and enzyme content. The mortality rate was not reduced. These results do not recommend the use of SRIF in the treatment of acute pancreatitis.

Citing Articles

Drug Therapy for Acute Pancreatitis.

Bi Y, Atwal T, Vege S Curr Treat Options Gastroenterol. 2015; 13(3):354-68.

PMID: 26099966 DOI: 10.1007/s11938-015-0058-7.

Pharmacologic therapy for acute pancreatitis.

Kambhampati S, Park W, Habtezion A World J Gastroenterol. 2014; 20(45):16868-80.

PMID: 25493000 PMC: 4258556. DOI: 10.3748/wjg.v20.i45.16868.

Review of experimental animal models of acute pancreatitis.

Su K, Cuthbertson C, Christophi C HPB (Oxford). 2008; 8(4):264-86.

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Effects of octreotide on acute necrotizing pancreatitis in rabbits.

Czako L, Hegyi P, Takacs T, Gog C, Farkas A, Mandy Y World J Gastroenterol. 2004; 10(14):2082-6.

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A randomised, double blind, multicentre trial of octreotide in moderate to severe acute pancreatitis.

Uhl W, Buchler M, Malfertheiner P, Beger H, Adler G, Gaus W Gut. 1999; 45(1):97-104.

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