Lysine Transport in Human Kidney: Evidence for Two Systems
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Experiments with slices of human kidney cortex from two control subjects demonstrated two distinct transport systems for lysine (alpha and beta) which differ greatly in affinity and capacity. Both systems were found in kidney from two patients with cystinuria. Studies with rat kidney confirmed these findings. These experiments defined only a single transport system for cystine in kidney from both control and cystinuric subjects.
Wang B, Li J, Gao J, Cai P, Han X, Tian C Biotechnol Biofuels. 2017; 10:17.
PMID: 28115989 PMC: 5244594. DOI: 10.1186/s13068-017-0705-4.
Renal transport of lysine and arginine in lysinuric protein intolerance.
Kato T, Mizutani N, Ban M Eur J Pediatr. 1982; 139(3):181-4.
PMID: 6819142 DOI: 10.1007/BF01377352.
Dibasic amino acid transport: lessons from human disease.
THIER S Trans Am Clin Climatol Assoc. 1983; 95:132-6.
PMID: 6433526 PMC: 2279615.
Transport of L-lysine by rat renal brush border membrane vesicles.
Stieger B, Stange G, Biber J, Murer H Pflugers Arch. 1983; 397(2):106-13.
PMID: 6408605 DOI: 10.1007/BF00582047.
Scriver C J Clin Invest. 1968; 47(4):823-35.
PMID: 5641621 PMC: 297232. DOI: 10.1172/JCI105776.