Studies on the Biochemistry of Penicillium Charlesii. Influence of Various Dicarboxylic Acids on Galactocarolose Synthesis

Overview

Journal Biochem J

Specialty Biochemistry

Date 1966 Sep 1

PMID 5969282

Citations 5

Authors

J M Jordan

J E Gander

Affiliations

Soon will be listed here.

Abstract

1. It has been shown that Penicillium charlesii continues to synthesize galactocarolose when l-malic acid, malonic acid, succinic acid, fumaric acid, maleic acid or oxaloglycollic acid is substituted for dl-tartaric acid in the Raulin-Thom nutrient medium. 2. The quantity of galactocarolose synthesized per g. of mycelia was markedly decreased by substitution of l-malic acid, malonic acid, succinic acid, fumaric acid or maleic acid for dl-tartaric acid. Substitution of oxaloglycollic acid for dl-tartaric acid did not depress the galactocarolose synthesized/g. of mycelia; however, the quantity of fungal mass formed was decreased approximately fivefold. 3. Based upon (14)C incorporation into galactocarolose, succinic acid, fumaric acid or malonic acid did not serve as direct precursors of galactose as did tartaric acid. Oxaloglycollic acid, l-malic acid and maleic acid were not tested. 4. The relative quantity of galactocarolose synthesized per g. of mycelia decreased as the concentration of diammonium dicarboxylate added to the growth medium was increased. Tartaric acid, oxaloglycollic acid, fumaric acid and malonic acid were tested. 5. The quantity of mycelia formed and the quantity of galactocarolose synthesized per g. of mycelia were greater when the growth medium contained l-tartrate than when it contained d-tartrate.

Citing Articles

The biosynthesis of galactofuranosyl residues in galactocarolose.

Trejo A, Haddock J, Chittenden G, BADDILEY J Biochem J. 1971; 122(1):49-57.

PMID: 5124813 PMC: 1176686. DOI: 10.1042/bj1220049.

Isolation, purification, and properties of Penicillium charlesii alkaline protease.

Abbas C, Groves S, Gander J J Bacteriol. 1989; 171(10):5630-7.

PMID: 2793829 PMC: 210407. DOI: 10.1128/jb.171.10.5630-5637.1989.

Purification of a new galactanase from Penicillium oxalicum catalysing the hydrolysis of beta-(1----5)-galactofuran linkages.

Reyes F, Alfonso C, Martinez M, Prieto A, Santamaria F, Leal J Biochem J. 1992; 281 ( Pt 3):657-60.

PMID: 1536645 PMC: 1130740. DOI: 10.1042/bj2810657.

In vivo biosynthesis of peptidophosphogalactomannan in Penicillium charlesii.

Drewes L, Rick P, Gander J Arch Microbiol. 1975; 104(2):101-4.

PMID: 1156099 DOI: 10.1007/BF00447308.

Exocellular glycopeptide from a Penicillium charlesii mutant incapable of growth on D-galactose.

Drewes L, Gander J J Bacteriol. 1975; 121(2):675-81.

PMID: 1112774 PMC: 245981. DOI: 10.1128/jb.121.2.675-681.1975.

References

ROSENBERGER R, Shilo M . Repression of inducible tartrate dehydratases in Pseudomonas strains. J Gen Microbiol. 1963; 31:413-20. DOI: 10.1099/00221287-31-3-413. View

Martin W, FOSTER J . Production of trans-L-epoxysuccinic acid by fungi and its microbiological conversion to meso-tartartic acid. J Bacteriol. 1955; 70(4):405-14. PMC: 386240. DOI: 10.1128/jb.70.4.405-414.1955. View

Bentley R, KEIL J . Tetronic acid biosynthesis in molds. II. Formation of penicillic acid in Penicillium cyclopium. J Biol Chem. 1962; 237:867-73. View

Dubois M, GILLES K, Hamilton J, Rebers P, Smith F . A colorimetric method for the determination of sugars. Nature. 1951; 168(4265):167. DOI: 10.1038/168167a0. View

CLUTTERBUCK P, HAWORTH W, RAISTRICK H, Smith G, Stacey M . Studies in the biochemistry of micro-organisms: The metabolic products of Penicillium Charlesii G. Smith. Biochem J. 1934; 28(1):94-110. PMC: 1253161. DOI: 10.1042/bj0280094. View

LA RIVIERE J . Intermediate products in tartrate decomposition by cell-free extracts of Pseudomonas putida under anaerobic conditions. Biochim Biophys Acta. 1956; 21(1):190-1. DOI: 10.1016/0006-3002(56)90122-6. View

Bandurski R, AXELROD B . The chromatographic identification of some biologically important phosphate esters. J Biol Chem. 1951; 193(1):405-10. View

Kun E, Garcia Hernandez M . The oxidation of tartaric acid by an enzyme system of mitochondria. J Biol Chem. 1956; 218(1):201-11. View

DAGLEY S, Trudgill P . THE METABOLISM OF TARTARIC ACID BY A PSEUDOMONAS. A NEW PATHWAY. Biochem J. 1963; 89:22-31. PMC: 1202266. DOI: 10.1042/bj0890022. View

10.

Wallenfels K, KURZ G . [On the specificity of galactose dehydrogenase from Pseudomonas saccharophila and its use as an analytical aid]. Biochem Z. 1962; 335:559-73. View

11.

BIRKINSHAW J, RAISTRICK H . Studies in the biochemistry of micro-organisms: The production of luteic acid from various sources of carbon by Penicillium luteum Zukal. Biochem J. 1933; 27(2):370-5. PMC: 1252889. DOI: 10.1042/bj0270370. View

12.

SCHONBAUM E . Adrenocortical function in rats exposed to low environmental temperatures. Fed Proc. 1960; 19(Suppl 5):85-8. View

13.

Gander J . Biogenesis of galactocarolose by Penicillium charlesii. I. Incorporation of C14 from glucose-C14 and DL-tartrate-1,4-C14 into polyglactose. Arch Biochem Biophys. 1960; 91:307-9. DOI: 10.1016/0003-9861(60)90505-1. View

14.

Su J, HASSID W . Carbohydrates and nucleotides in the red alga Porphyra perforata. I. Isolation and identification of carbohydrates. Biochemistry. 1962; 1:468-74. DOI: 10.1021/bi00909a016. View

15.

HAWORTH W, RAISTRICK H, Stacey M . Polysaccharides synthesised by micro-organisms: The molecular structure of galactocarolose produced from glucose by Penicillium Charlesii G. Smith. Biochem J. 1937; 31(4):640-4. PMC: 1266983. DOI: 10.1042/bj0310640. View

16.

Cleland W, Johnson M . Studies on the formation of oxalic acid by Aspergillus niger. J Biol Chem. 1956; 220(2):595-606. View