Tetraethylammonium and Tetrodotoxin: Effects on Cochlear Potentials

Overview

Journal Science

Specialty Science

Date 1966 Mar 25

PMID 5909587

Citations 7

Authors

Y Katsuki

K Yanagisawa

J Kanzaki

Affiliations

Soon will be listed here.

Abstract

Tetraethylammonium chloride, which is believed to decrease potassium conductance, and tetrodotoxin, which apparently decreases sodium conductance in nerve fibers, were introduced iontophoretically into the organ of Corti or the scala media of guinea pig cochlea. The former depressed the direct-current endocochlear potential and also the alternating-current cochlear microphonics (the receptor potential of the ear), but tetrodotoxin was ineffective except on the nerve impulses.

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Permeability to potassium of the endolymph-perilymph barrier and its possible relation to hair cell function.

Konishi T, Salt A Exp Brain Res. 1980; 40(4):457-63.

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The effects of intracochlear cyanide and tetrodotoxin on the properties of single cochlear nerve fibres in the cat.

Evans E, Klinke R J Physiol. 1982; 331:385-408.

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A study of the electrochemistry and osmotic relationships of the cochlear fluids in the neonatal rat at the time of the development of the endocochlear potential.

BOSHER S, Warren R J Physiol. 1971; 212(3):739-61.

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A mechanism by which the hair cells of the inner ear transduce mechanical energy into a modulated train of action potentials.

Malcolm R J Gen Physiol. 1974; 63(6):757-72.

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