Aflatoxin B1: Binding to DNA in Vitro and Alteration of RNA Metabolism in Vivo

Overview

Journal Science

Specialty Science

Date 1966 Mar 25

PMID 5909585

Citations 35

Authors

M B Sporn

C W DINGMAN

H L Phelps

G N Wogan

Affiliations

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Abstract

Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.

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