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Quantification of the Lymphocytic Infiltrate in Jejunal Epithelium in Giardiasis

Overview
Journal Clin Exp Immunol
Publisher Oxford University Press
Specialty Allergy & Immunology
Date 1977 Sep 1
PMID 589861
Citations 14
Authors
S G Wright
A M Tomkins
Affiliations
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Abstract

The intraepithelial lymphocytes of the jejunal mucosa from patients with giardiasis and from control patients were counted in coded serial sections. Patients with giardiasis and normal intestinal absorption and control patients who had lived and travelled in tropical areas had similar counts, which were higher than those reported for controls from temperate areas. Where giardiasis was accompanied by malabsorption of one substance the mean count was significantly higher than that of controls (P less than 0.02). In those patients with giardiasis and malabsorption of two or three substances the mean count was significantly higher than that of controls (P less than 0.02) and that of patients with giardiasis and normal absorption (P less than 0.05). After treatment, intraepithelial lymphocyte counts declined consistently in patients with malabsorption. An association between raised intraepithelial lymphocyte counts and malabsorption is indicated. The possible significance of this finding is discussed.

Citing Articles

Disaccharidase activity in male and female C57BL/6 mice infected with Giardia muris.

Daniels C, Belosevic M Parasitol Res. 1995; 81(2):143-7.

PMID: 7731922 DOI: 10.1007/BF00931620.

Disaccharidase deficiencies in Mongolian gerbils (Meriones unguiculatus) protected against Giardia lamblia.

Mohammed S, Faubert G Parasitol Res. 1995; 81(7):582-90.

PMID: 7479650 DOI: 10.1007/BF00932025.

Features of small intestinal pathology (epithelial cell kinetics, intraepithelial lymphocytes, disaccharidases) in a primary Giardia muris infection.

Gillon J, Al Thamery D, Ferguson A Gut. 1982; 23(6):498-506.

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Small intestinal nodular lymphoid hyperplasia in patients with giardiasis and normal serum immunoglobulins.

Ward H, Jalan K, Maitra T, Agarwal S, Mahalanabis D Gut. 1983; 24(2):120-6.

PMID: 6852622 PMC: 1420170. DOI: 10.1136/gut.24.2.120.

Giardiasis.

Anand B Indian J Pediatr. 1983; 50(405):417-22.

PMID: 6368383 DOI: 10.1007/BF02753384.

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