Reversal by Adenine of the Ethionine-induced Lipid Accumulation in the Endoplasmic Reticulum of the Rat Liver. A Preliminary Report

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 1965 Dec 1

PMID 5885431

Citations 19

Authors

C M BAGLIO

E Farber

Affiliations

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Abstract

Within 3.5 to 4 hours after thionine administration, numerous small osmiophilic bodies, liposomes, appear in the endoplasmic reticulum of the liver cells. By fusion, the liposomes lead to the formation of larger collections of fat, giant liposomes. Adenine administration to ethionine-treated rats removes the liposomes from the hepatocytes and causes the transitory appearance of osmiophilic droplets in the sinusoidal space of Disse. The characteristic disaggregation of hepatic polysomes seen in the liver after ethionine administration is corrected by the injection of adenine.

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