Histones and Basic Polyamino Acids Stimulate the Uptake of Albumin by Tumor Cells in Culture

Overview

Journal Science

Specialty Science

Date 1965 Oct 22

PMID 5835786

Citations 55

Authors

H J RYSER

R Hancock

Affiliations

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Abstract

Basic proteins and polyamino acids are taken up by mammalian cells at rates up to 3000 times greater than serum albumin. When given together with serum albumin they increase the albumin uptake by a factor that correlates with their own rate of uptake and can reach more than 50-fold. The lowest threshold of activity detected (10(-10)M)is comparable to the activities of the most potent membrane-active agents.

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