The Effect of Hypothalamic Lesions on the Melanocyte-stimulating Hormone Content and Histology of the Pars Intermedia of the Rat Pituitary Gland

Overview

Journal J Physiol

Specialty Physiology

Date 1969 Jul 1

PMID 5821868

Citations 5

Authors

A Howe

A J Thody

Affiliations

Soon will be listed here.

Abstract

1. The effect of bilateral lesions in the anterior hypothalamus on the histology and content of melanocyte-stimulating hormone (MSH) of the pars intermedia has been studied in the adult male rat.2. By 7-15 days striking histological changes, suggestive of hyperactivity, were evident. These changes were accompanied by an elevated MSH content, which was particularly noticeable at 7 days.3. By 7 days there was an increase in the acid phosphatase activity of pars intermedia cells, as demonstrated histochemically.4. It was concluded that a hypothalamic control system exists for the mammalian pars intermedia and may involve both inhibitory and excitatory components.

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