Release of Motilin After Duodenal Acidification

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1976 Apr 24

PMID 58151

Citations 15

Authors

P Mitznegg

S R Bloom

W Domschke

S Domschke

E Wunsch

L DEMLING

Affiliations

Soon will be listed here.

Abstract

The physiological stimulus leading to motilin release in man has not yet been determined. Six healthy volunteers had 3-minute intraduodenal infusions of acid, alkali, or saline solutions. After infusing acid, plasma-motilin rose by 90% at 4 min and was still significantly raised at 45 min, whereas there was an insignificant fall in plasma-motilin after alkali and no change after saline solution. Release of motilin after duodenal acidification may be an important factor in inhibiting gastric emptying.

Citing Articles

The Role of Gasotransmitters in Gut Peptide Actions.

Verbeure W, Goor H, Mori H, van Beek A, Tack J, van Dijk P Front Pharmacol. 2021; 12:720703.

PMID: 34354597 PMC: 8329365. DOI: 10.3389/fphar.2021.720703.

Human duodenal motor activity in response to acid and different nutrients.

Schwartz M, Samsom M, Smout A Dig Dis Sci. 2001; 46(7):1472-81.

PMID: 11478499 DOI: 10.1023/a:1010691905050.

Effect of solution of low pH on releases of beta-endorphin-like immunoreactivity and ACTH-like immunoreactivity from human gastric antral mucosa in vitro.

Matsumura M, Wada H, Saito S Gastroenterol Jpn. 1983; 18(3):210-5.

PMID: 6307802 DOI: 10.1007/BF02774962.

Does gastric acid release plasma somatostatin in man?.

Lucey M, Wass J, Fairclough P, OHare M, Kwasowski P, Penman E Gut. 1984; 25(11):1217-20.

PMID: 6149977 PMC: 1432309. DOI: 10.1136/gut.25.11.1217.

Effect of synthetic motilin on gastric motor activity in conscious dogs.

Ito Z, Takeuchi S, AIZAWA I, Takayanagi R Am J Dig Dis. 1977; 22(9):813-9.

PMID: 900097 DOI: 10.1007/BF01694513.