The Metabolism of Lindance and Its Metabolites Gamma-2,3,4,5,6-pentachlorocyclohexene, Pentachlorobenzene, and Pentachlorophenol in Rats and the Pathways of Lindance Metabolism

Overview

Journal J Environ Sci Health B

Specialties Environmental Health
Toxicology

Date 1976 Jan 1

PMID 57975

Citations 3

Authors

R Engst

R M Macholz

M Kujawa

H J Lewerenz

R Plass

Affiliations

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Abstract

The metabolism of lindane and its metabolites, gamma-PCCH, PCB, and PCP, has been studied in rats. Urine, faeces, blood and important organs were analyzed for free metabolities and those bound as beta-glucuronides. TeCCOL was identified as a main metabolite by GC/MS and gamma-PCCH has been evaluated toxicologically. A degradation scheme, based on experimental results and comprising only one hypothetical metabolite is proposed and discussed.

Citing Articles

Studies on toxic effects of gamma-pentachlorocyclo-hexene (PCCH).

Macholz R, Kujawa M, Lewerenz H, Plass R, Engst R Bull Environ Contam Toxicol. 1986; 36(1):92-4.

PMID: 2416373 DOI: 10.1007/BF01623479.

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the in vivo and in vitro dechlorination of pentachlorophenol.

Ahlborg U, Thunberg T Arch Toxicol. 1978; 40(1):55-61.

PMID: 580376 DOI: 10.1007/BF00353279.

Anaerobic dechlorination and degradation of hexachlorocyclohexane isomers by anaerobic and facultative anaerobic bacteria.

JAGNOW G, Haider K, Ellwardt P Arch Microbiol. 1977; 115(3):285-92.

PMID: 74989 DOI: 10.1007/BF00446454.