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Hypothalamic--pituitary Function in Depressive Illness: Insensitivity to Hylycaemia

Overview
Journal Br Med J
Specialty General Medicine
Date 1969 Jul 5
PMID 5787280
Citations 3
Authors
B J Carroll
Affiliations
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Abstract

The insulin tolerance test was performed in 16 severely depressed patients on admission to hospital and after treatment with electric convulsion therapy. The mean plasma cortisol response to hypoglycaemia was significantly impaired before treatment, particularly in the patients who also showed resistance to dexamethasone suppression. The results are consistent with hypothalamic-pituitary insensitivity to hypoglycaemia in these subjects.

Citing Articles

Clinical associations of 11-hydroxycorticosteroid suppression and non-suppression in severe depressive illnesses.

Carroll B, Davies B Br Med J. 1970; 1(5699):789-91.

PMID: 5443383 PMC: 1699666. DOI: 10.1136/bmj.1.5699.789.

[Causal analytic studies on demonstration of neuroendocrine parameters in combined hypoglycemia test in depressive subgroups].

Czernik A, Steinmeyer E Eur Arch Psychiatry Neurol Sci. 1985; 235(2):110-8.

PMID: 3933981 DOI: 10.1007/BF00633482.

The effects of opioid drugs and of lithium on steroidogenesis in rat adrenal cell suspensions.

Gibson A, GINSBURG M, Hall M, Hart S Br J Pharmacol. 1979; 65(4):671-6.

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