Role of Acidosis in Renal Osteomalacia

Overview

Journal Br Med J

Specialty General Medicine

Date 1969 May 3

PMID 5780454

Citations 4

Authors

M Cochran

B E Nordin

Affiliations

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Abstract

Of nine patients with uraemic osteomalacia, the underlying renal lesion was pyelonephritis in seven. All of the patients were characterized by impairment of acidifying power and severe metabolic acidosis. It is suggested that metabolic acidosis may be a definite factor in the pathogenesis of uraemic osteomalacia, possibly by reducing the proportion of trivalent phosphate in the plasma and/or by reducing plasma calcium.

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