Effects of Diet and Microsomal Enzyme Induction on the Toxicity of Dimethyl Nitrosamine

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1969 Feb 1

PMID 5773143

Citations 12

Authors

A E McLean

H G Verschuuren

Affiliations

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Citing Articles

Induction of kidney tumours by a single dose of dimethylnitrosamine: dose response and influence of diet and benzo(a)pyrene pretreatment.

Swann P, Kaufman D, MAGEE P, Mace R Br J Cancer. 1980; 41(2):285-94.

PMID: 7370168 PMC: 2010195. DOI: 10.1038/bjc.1980.41.

Cellular injury and carcinogenesis. The effect of a protein-free high-carbohydrate diet on the metabolism of dimethylnitrosamine in the rat.

Swann P, McLean A Biochem J. 1971; 124(2):283-8.

PMID: 5158489 PMC: 1177143. DOI: 10.1042/bj1240283.

The effect of prior dosing with phenobarbitone and -diethylaminoethyl diphenylpropyl acetate (SKF525A) on the toxicity and liver lesion caused by ngaione in the mouse.

Seawright A, Hrdlicka J Br J Exp Pathol. 1972; 53(3):242-52.

PMID: 5055710 PMC: 2072464.

Protection by a small dose of carbon tetrachloride against the toxic effects of dimethylnitrosamine in rats.

POUND A, LAWSON T Br J Exp Pathol. 1974; 55(2):203-12.

PMID: 4835806 PMC: 2072530.

The evaluation of chemical mutagenicity data in relation to population risk: some factors affecting the host-mediated assay response.

Zeiger E Environ Health Perspect. 1973; 6:101-9.

PMID: 4592362 PMC: 1475527. DOI: 10.1289/ehp.7306101.

References

Orrenius S, Ericsson J, Ernster L . Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study. J Cell Biol. 1965; 25(3):627-39. PMC: 2106691. DOI: 10.1083/jcb.25.3.627. View

Lijinsky W, Loo J, Ross A . Mechanism of alkylation of nucleic acids by nitrosodimethylamine. Nature. 1968; 218(5147):1174-5. DOI: 10.1038/2181174b0. View

McLean A, MCLEAN E . The effect of diet and 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) on microsomal hydroxylating enzymes and on sensitivity of rats to carbon tetrachloride poisoning. Biochem J. 1966; 100(2):564-71. PMC: 1265172. DOI: 10.1042/bj1000564. View