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Sodium Ions and the Secretion of Catecholamines

Overview
Journal J Physiol
Specialty Physiology
Date 1969 Feb 1
PMID 5765858
Citations 15
Authors
P Banks
R Biggins
R Bishop
B Christian
N Currie
Affiliations
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Abstract

1. Perfusion of bovine adrenal glands with a potassium-free Tyrode solution results in an increased spontaneous release of catecholamines and an increased response to stimulation with carbamylcholine.2. Perfusion with a Tyrode solution containing 70 mM-KCl causes a marked secretion of catecholamines and a subsequent inhibition of secretion in response to stimulation with carbamylcholine.3. Perfusion with sodium-free media abolishes or severely reduces the secretory response of the gland to carbamylcholine and to 70 mM-KCl although the basal secretion shows an initial rise.4. Perfusion with sodium-deficient media permits some retention of the secretory response.5. A possible role for intracellular sodium ions in the secretion of catecholamines is discussed.

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References
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