Non-specificity of "behavioral Despair" As an Animal Model of Depression

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1979 Dec 7

PMID 575094

Citations 15

Authors

M D SCHECHTER

W T Chance

Affiliations

Soon will be listed here.

Abstract

When mice are forced to swim in a restricted space, they will cease attempts to escape and adopt a characteristic immobile posture which can be readily identified and timed. Imipramine decreased the duration of immobility in a 4 min swimming test in a dose-related manner. Likewise, caffeine, triiodothyronine and pentobarbital reduced immobility. These latter findings shed doubt upon the specificity of the behavioral despair swimming test to identify substances with antidepressant activity.

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