Appearance of Prostaglandin F2-alpha in Human Blood During Labour

Overview

Journal Br Med J

Specialty General Medicine

Date 1968 Dec 7

PMID 5723366

Citations 15

Authors

S M Karim

Affiliations

Soon will be listed here.

Abstract

Blood samples from over 70 pregnant women have been examined for the presence of four prostaglandins. Samples obtained from women not in labour at different gestation periods and at term contained no detectable amounts of prostaglandins. Prostaglandin F(2alpha) was present in samples of blood obtained during normal spontaneous labour. The appearance of this substance in the blood preceded the uterine contraction. Whether prostaglandins play a part in the process of normal labour is still conjectural.

Citing Articles

PGF induces a pro-labour phenotypical switch in human myometrial cells that can be inhibited with PGF receptor antagonists.

Hamshaw I, Straube A, Stark R, Baxter L, Alam M, Wever W Front Pharmacol. 2023; 14:1285779.

PMID: 38155905 PMC: 10752971. DOI: 10.3389/fphar.2023.1285779.

Prostaglandins in biofluids in pregnancy and labour: A systematic review.

Wood E, Hornaday K, Slater D PLoS One. 2021; 16(11):e0260115.

PMID: 34793529 PMC: 8601582. DOI: 10.1371/journal.pone.0260115.

The impact of high apparent temperature on spontaneous preterm delivery: a case-crossover study.

Avalos L, Chen H, Li D, Basu R Environ Health. 2017; 16(1):5.

PMID: 28143601 PMC: 5286689. DOI: 10.1186/s12940-017-0209-5.

Whole blood gene expression profile associated with spontaneous preterm birth in women with threatened preterm labor.

Heng Y, Pennell C, Chua H, Perkins J, Lye S PLoS One. 2014; 9(5):e96901.

PMID: 24828675 PMC: 4020779. DOI: 10.1371/journal.pone.0096901.

Climate extremes and the length of gestation.

Dadvand P, Basagana X, Sartini C, Figueras F, Vrijheid M, de Nazelle A Environ Health Perspect. 2011; 119(10):1449-53.

PMID: 21659038 PMC: 3230440. DOI: 10.1289/ehp.1003241.

References

Caldeyro-Barcia R, POSEIRO J . Oxytocin and contractility of the pregnant human uterus. Ann N Y Acad Sci. 1959; 75:813-30. DOI: 10.1111/j.1749-6632.1959.tb44593.x. View

Hawker R, WALMSLEY C, ROBERTS V, BLACKSHAW J, DOWNES J . Oxytocic activity of blood in parturient and lactating women. J Clin Endocrinol Metab. 1961; 21:985-95. DOI: 10.1210/jcem-21-8-985. View

Gunther M . The posterior pituitary and labour. Br Med J. 1948; 1(4550):567. PMC: 2090079. DOI: 10.1136/bmj.1.4550.567-b. View

Samuelsson B . ISOLATION AND IDENTIFICATION OF PROSTAGLANDINS FROM HUMAN SEMINAL PLASMA. 18. PROSTAGLANDINS AND RELATED FACTORS. J Biol Chem. 1963; 238:3229-34. View

Bygdeman M, Eliasson R . A COMPARATIVE STUDY ON THE EFFECT OF DIFFERENT PROSTAGLANDIN COMPOUNDS ON THE MOTILITY OF THE ISOLATED HUMAN MYOMETRIUM. Med Exp Int J Exp Med. 1963; 9:409-15. DOI: 10.1159/000135384. View

Karim S, Devlin J . Prostaglandin content of amniotic fluid during pregnancy and labour. J Obstet Gynaecol Br Commonw. 1967; 74(2):230-4. DOI: 10.1111/j.1471-0528.1967.tb14866.x. View

RAMWELL P, Shaw J, DOUGLAS W, Poisner A . Efflux of prostaglandin from adrenal glands stimulated with acetylcholine. Nature. 1966; 210(5033):273-4. DOI: 10.1038/210273a0. View

Eglinton G, RAPHAEL R, Smith G, Hall W, Pickles V . ISOLATION AND IDENTIFICATION OF TWO SMOOTH MUSCLE STIMULANTS FROM MENSTRUAL FLUID. Nature. 1963; 200:960 PASSIM. DOI: 10.1038/200960a0. View

Palmisano A . [Experimental contribution to the study of determinism of labor. III. Latest data on eutocin]. Boll Soc Ital Biol Sper. 1950; 26(5):626-7. View

10.

CENTARO A, PERITI P . [CLINICAL AND EXPERIMENTAL RESEARCH ON SOME ENDOGENOUS POLYPEPTIDES OF OBSTETRICAL AND GYNECOLOGICAL IMPORTANCE]. Riv Ostet Ginecol. 1963; 18:263-88. View

11.

Horton E . Biological activities of pure prostaglandins. Experientia. 1965; 21(3):113-8. DOI: 10.1007/BF02141963. View

12.

COCH J, BROVETTO J, Cabot H, FIELITZ C, Caldeyro-Barcia R . OXYTOCIN-EQUIVALENT ACTIVITY IN THE PLASMA OF WOMEN IN LABOR AND DURING THE PUERPERIUM. Am J Obstet Gynecol. 1965; 91:10-7. DOI: 10.1016/0002-9378(65)90580-6. View

13.

CENTARO A, PERITI P, De Laurentiis G . [Oxytocin in the blood and oxytocinase activity of the blood and myometrium in women during labor]. Riv Ostet Ginecol. 1961; 16:297-326. View

14.

KOREN Z, Pfeifer Y, SULMAN F . SEROTONIN CONTENT OF HUMAN PLACENTA AND FETUS DURING PREGNANCY. Am J Obstet Gynecol. 1965; 93:411-5. DOI: 10.1016/0002-9378(65)90070-0. View

15.

Karim S, Sandler M, Williams E . Distribution of prostaglandins in human tissues. Br J Pharmacol Chemother. 1967; 31:340-4. PMC: 1557379. DOI: 10.1111/j.1476-5381.1967.tb02003.x. View

16.

PERITI P, CENTARO A, SICUTERI F, LEOCANI B . [Blood bradykininogen during labor]. Boll Soc Ital Biol Sper. 1962; 38:672-4. View

17.

Williams E, Karim S, Sandler M . Prostaglandin secretion by medullary carcinoma of the thyroid. A possible cause of the associated idarrhoea. Lancet. 1968; 1(7532):22-3. DOI: 10.1016/s0140-6736(68)90010-x. View

18.

HALFPAP E . [THYMUS AND LABOR]. Zentralbl Gynakol. 1965; 87:185-91. View

19.

Armstrong D, Stewart J . Spontaneous plasma kinin formation in human plasma collected during labour. Nature. 1960; 188:1193. DOI: 10.1038/1881193a0. View

20.

Pickles V, Hall W . SOME PHYSIOLOGICAL PROPERTIES OF THE 'MENSTRUAL STIMULANT' SUBSTANCES A1 AND A2. J Reprod Fertil. 1963; 6:315-7. DOI: 10.1530/jrf.0.0060315. View