Biochemical Effects of the Hypoglycaemic Compound Pent-4-enoic Acid and Related Non-hypoglycaemic Fatty Acids. Carbohydrate Metabolism

Overview

Journal Biochem J

Specialty Biochemistry

Date 1968 Dec 1

PMID 5701682

Citations 14

Authors

A E Senior

H S Sherratt

Affiliations

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Abstract

1. The effects of the hypoglycaemic compound, pent-4-enoic acid, and of four structurally related non-hypoglycaemic compounds (pent-2-enoic acid, pentanoic acid, cyclopropanecarboxylic acid and cyclobutanecarboxylic acid), on glycolysis, glucose oxidation and gluconeogenesis in some rat tissues were determined. 2. None of the compounds at low concentrations inhibited glycolysis by particle-free supernatant fractions from rat liver, skeletal muscle and intestinal mucosa, though there was inhibition by cyclopropanecarboxylic acid and cyclobutanecarboxylic acid at 3mm concentration. 3. Pent-4-enoic inhibited the oxidation of [1-(14)C]palmitate by rat liver slices, but did not increase the oxidation of [U-(14)C]glucose. 4. Pent-4-enoic acid (0.01mm) strongly inhibited gluconeogenesis by rat kidney slices from pyruvate or succinate, but none of the other compounds inhibited significantly at low concentrations. 5. There was also some inhibition of gluconeogenesis in kidney slices from rats injected with pent-4-enoic acid. 6. The mechanism of the hypoglycaemic effect of pent-4-enoic acid is discussed; it is suggested that there is an inhibition of fatty acid and ketone-body oxidation and of gluconeogenesis so that glucose reserves become exhausted, leading to hypoglycaemia. 7. The mechanism of the hypoglycaemic action of pent-4-enoic acid appears to be similar to that of hypoglycin.

Citing Articles

Biochemical effects of the hypoglycaemic compound pent--4-enoic acid and related non-hypoglycaemic fatty acids.

Senior A, Robson B, Sherratt H Biochem J. 1968; 110(3):511-9.

PMID: 5701681 PMC: 1187380. DOI: 10.1042/bj1100511.

Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Oxidative phosphorylation and mitochondrial oxidation of pyruvate, 3-hydroxybutyrate and tricarboxylic acid-cycle intermediates.

Senior A, Sherratt H Biochem J. 1968; 110(3):499-509.

PMID: 5701680 PMC: 1187379. DOI: 10.1042/bj1100499.

Hypoglycin toxicity in rats. II. Modification by riboflavin of mitochondrial changes in liver.

Brooks S, Audretsch J Am J Pathol. 1971; 62(3):309-20.

PMID: 5544578 PMC: 2047417.

Studies on hypoglycin toxicity in rats. I. Changes in hepatic ultrastructure.

Brooks S, Audretsch J Am J Pathol. 1970; 59(1):161-80.

PMID: 5441716 PMC: 2032857.

Biochemical effects of hypoglycaemic compound diphenyleneiodonium in rat liver mitochondria: inhibition of adenosine triphosphate synthesis.

Holland P, Sherrat H Biochem J. 1971; 121(3):42P.

PMID: 5119778 PMC: 1176624.

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