Transport and Accumulation of Alpha-aminoisobutyric Acid (A.I.B.) in the Guinea Pig Placenta

Overview

Journal Pflugers Arch

Specialty Physiology

Date 1978 Nov 30

PMID 569817

Citations 1

Authors

J P van Dijk

B K van Kreel

Affiliations

Soon will be listed here.

Abstract

Active transport of A.I.B. from mother to fetus was studied. This was done in the intact animal and using the isolated placenta, artificially perfused at both sides. It was shown that A.I.B. is actively accumulated in the placental cells. An estimate of the kinetic constants is given. It is shown that this accumulation takes place predominantly from the maternal side of the placenta. A.I.B. that has been accumulated is cleared to the maternal and fetal circulation in equal amounts. So the netto active transport from mother to fetus is brought about by an unequal distribution of carriers, the maternal side being most active.

Citing Articles

Transport specificity for neutral and basic amino acids at maternal and fetal interfaces of the guinea-pig placenta.

Eaton B, Mann G, Yudilevich D J Physiol. 1982; 328:245-58.

PMID: 7131314 PMC: 1225656. DOI: 10.1113/jphysiol.1982.sp014262.

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