Herpes Simplex Virus in Mice: Electron Microscopy of Neural Spread

Overview

Journal Science

Specialty Science

Date 1968 Oct 4

PMID 5675180

Citations 23

Authors

E R RABIN

A B Jenson

J L Melnick

Affiliations

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Abstract

Herpes simplex virus rapidly infected the trigeminal nerves of mice after intranasal inoculation. Centripetal neural spread was suggested by histologic evidence of encephalitis in the area of attachment of the trigeminal nerve. Furthermore, electron microscopy revealed virus replication primarily within Schwann cells of the trigeminal nerve, and neurons of the gasserian ganglion.

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