Enterohepatic Circulation of Bile Acids After Cholecystectomy

Overview

Journal Gut

Specialty Gastroenterology

Date 1978 Jul 1

PMID 567165

Citations 37

Authors

E Roda

R Aldini

G Mazzella

A Roda

C Sama

D Festi

L Barbara

Affiliations

Soon will be listed here.

Abstract

Bile acid metabolism was investigated in 10 patients after cholecystectomy, 10 gallstone patients, and 10 control subjects. Diurnal variations of serum levels of cholic and chenodeoxycholic acid conjugates were not abolished by cholecystectomy. Cholic acid pool size was significantly reduced in cholecystectomised patients and the fractional turnover rate and the rate of intestinal degradation of bile acid showed a significant increase. In cholecystectomised patients fasting bile was supersaturated in cholesterol, though less than in gallstone patients, but, in both, feeding resulted in improvement of cholesterol solubility in bile. These data suggest that after cholecystectomy the small intestine alone acts as a pump in regulating the dynamics of the enterohepatic circulation of bile acids and that the improvement of cholesterol solubility in bile is due to a more rapid circulation of the bile acid pool in fasting cholecystectomised patients.

Citing Articles

Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study.

Park S, Jeong S, Park S, Song J, Kim S, Chang J Sci Rep. 2024; 14(1):3195.

PMID: 38326522 PMC: 10850095. DOI: 10.1038/s41598-024-53161-6.

Does postcholecystectomy increase the risk of colorectal cancer?.

Dong Z, Shi R, Li P, Song X, Dong F, Zhu J Front Microbiol. 2023; 14:1194419.

PMID: 37426004 PMC: 10324655. DOI: 10.3389/fmicb.2023.1194419.

Complex impacts of gallstone disease on metabolic syndrome and nonalcoholic fatty liver disease.

Lyu J, Lin Q, Fang Z, Xu Z, Liu Z Front Endocrinol (Lausanne). 2022; 13:1032557.

PMID: 36506064 PMC: 9727379. DOI: 10.3389/fendo.2022.1032557.

Cholecystectomy-induced secondary bile acids accumulation ameliorates colitis through inhibiting monocyte/macrophage recruitment.

Liu Y, Xu J, Ren X, Zhang Y, Ke Z, Zhou J Gut Microbes. 2022; 14(1):2107387.

PMID: 36050867 PMC: 9450905. DOI: 10.1080/19490976.2022.2107387.

Correlation between cholecystectomy and development of non-alcoholic liver disease in the mouse model.

Kim H, Lee S, Saeed W, Kim H, Oh J, Koh D Ann Transl Med. 2022; 10(15):814.

PMID: 36034996 PMC: 9403915. DOI: 10.21037/atm-21-5414.

References

Talalay P . Enzymic analysis of steroid hormones. Methods Biochem Anal. 1960; 8:119-43. DOI: 10.1002/9780470110249.ch3. View

Lindstedt S . The turnover of cholic acid in man: bile acids and steroids. Acta Physiol Scand. 1957; 40(1):1-9. DOI: 10.1111/j.1748-1716.1957.tb01473.x. View

Roda A, Roda E, Festi D, Sama C, Mazzella G, Aldini R . A radioimmunoassay of primary bile acid conjugates in human serum. Ric Clin Lab. 1977; 7(2):163-78. View

Roda A, Roda E, Aldini R, Mazzella G, Festi D, Sama C . Determination of 14CO2 in breath and 14C in stool after oral administration of cholyl-1-[14C]glycine: clinical application. Clin Chem. 1977; 23(11):2127-32. View

Roda A, Roda E, Aldini R, Festi D, Mazzella G, Sama C . Development, validation, and application of a single-tube radioimmunoassay for cholic and chenodeoxycholic conjugated bile acids in human serum. Clin Chem. 1977; 23(11):2107-13. View

SARLES H, Crotte C, GEROLAMI A, Mule A, Domingo N, Hauton J . Influence of cholestyramine, bile salt, and cholesterol feeding on the lipid composition of hepatic bile in man. Scand J Gastroenterol. 1970; 5(7):603-8. View

Redinger R, Small D . Bile composition, bile salt metabolism and gallstones. Arch Intern Med. 1972; 130(4):618-30. View

Larusso N, Korman M, Hoffman N, Hofmann A . Dynamics of the enterohepatic circulation of bile acids. Postprandial serum concentrations of conjugates of cholic acid in health, cholecystectomized patients, and patients with bile acid malabsorption. N Engl J Med. 1974; 291(14):689-92. DOI: 10.1056/NEJM197410032911401. View

Schersten T, Cahlin E, Jonsson J, Lindblad L, Nilsson S . Supersaturated bile--is it due to a metabolic disorder or to an impaired gallbladder?. Scand J Gastroenterol. 1974; 9(5):501-6. View

10.

Adler R, Metzger A, Grundy S . Biliary lipid secretion before and after cholecystectomy in American Indians with cholesterol gallstones. Gastroenterology. 1974; 66(6):1212-7. View

11.

Grundy S, DUANE W, Adler R, Aron J, Metzger A . Biliary lipid outputs in young women with cholesterol gallstones. Metabolism. 1974; 23(1):67-73. DOI: 10.1016/0026-0495(74)90105-x. View

12.

Simmonds W, Korman M, Go V, Hofmann A . Radioimmunoassay of conjugated cholyl bile acids in serum. Gastroenterology. 1973; 65(5):705-11. View

13.

Hepner G, Hofmann A, Malagelada J, SZCZEPANIK P, KLEIN P . Increased bacterial degradation of bile acids in cholecystectomized patients. Gastroenterology. 1974; 66(4):556-64. View

14.

Thomas P, Hofmann A . Letter: A simple calculation of the lithogenic index of bile: expressing biliary lipid composition on rectangular coordinates. Gastroenterology. 1973; 65(4):698-700. View

15.

ALMOND H, VLAHCEVIC Z, BELL Jr C, Gregory D, SWELL L . Bile acid pools, kinetics and biliary lipid composition before and after cholecystectomy. N Engl J Med. 1973; 289(23):1213-6. DOI: 10.1056/NEJM197312062892302. View

16.

Malagelada J, Go V, Summerskill W, GAMBLE W . Bile acid secretion and biliary bile acid composition altered by cholecystectomy. Am J Dig Dis. 1973; 18(6):455-9. DOI: 10.1007/BF01076595. View

17.

Pomare E . Regulation of bile salt pool size in man. Br Med J. 1973; 2(5862):338-40. PMC: 1589302. DOI: 10.1136/bmj.2.5862.338. View

18.

Grundy S, Metzger A, Adler R . Mechanisms of lithogenic bile formation in American Indian women with cholesterol gallstones. J Clin Invest. 1972; 51(12):3026-43. PMC: 332985. DOI: 10.1172/JCI107130. View

19.

Simmons F, Ross A, Bouchier I . Alterations in hepatic bile composition after cholecystectomy. Gastroenterology. 1972; 63(3):466-71. View

20.

Shaffer E, BRAASCH J, Small D . Bile composition at and after surgery in normal persons and patients with gallstones. Influence of cholecystectomy. N Engl J Med. 1972; 287(26):1317-22. DOI: 10.1056/NEJM197212282872603. View