Neuroleptic-induced "anhedonia" in Rats: Pimozide Blocks Reward Quality of Food

Overview

Journal Science

Specialty Science

Date 1978 Jul 21

PMID 566469

Citations 152

Authors

R A Wise

J Spindler

H deWit

G J Gerberg

Affiliations

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Abstract

The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.

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