Leukemia Virus Suppression of Antibody-forming Cells: Ultrastructure of Infected Spleens

Overview

Journal Science

Specialty Science

Date 1968 Jan 26

PMID 5634663

Citations 6

Authors

G Chan

M W RANCOURT

W S CEGLOWSKI

H Friedman

Affiliations

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Abstract

Infection of adult BALB/c mice with Friend disease virus results in a leukemia-like disease characterized by erythropoietic changes and splenomegaly. A marked depression of formation of cellular and serum antibody occurs in infected animals. Electron-microscopic examination of the ultrastructure of spleen sections from infected mice with depressed immunity revealed that virus particles can be detected only in immature blastlike lymphoid cells and not in plasmocytes characteristic of the immune response in spleens of noninfected mice immunized with sheep erythrocytes.

Citing Articles

Effect of 7,12-Dimethylbenz[a]anthracene on Phagocytosis and Antibody Formation in Friend Virus Leukemia.

Elliott S, SCHLOSS G Infect Immun. 1971; 3(2):217-20.

PMID: 16557956 PMC: 416134. DOI: 10.1128/iai.3.2.217-220.1971.

Suppression of established Friend virus leukemia by statolon. I. Demonstration of a latent infection in clinically normal mice.

Wheelock E, Caroline N, Moore R J Virol. 1969; 4(1):1-6.

PMID: 5817101 PMC: 375829. DOI: 10.1128/JVI.4.1.1-6.1969.

The immunodepressive effect of Friend virus. II. Reduction of splenic haemolysin-producing cells in primary and secondary responses.

Wedderburn N, SALAMAN M Immunology. 1968; 15(3):439-54.

PMID: 5681596 PMC: 1409469.

[Results of the macrophage migration test during the early phase of Rauscher leukemia].

Komitowski D, KURKA J Experientia. 1974; 30(6):648-9.

PMID: 4837090 DOI: 10.1007/BF01921523.

Immunodepression by mammalian viruses and plasmodia.

SALAMAN M Proc R Soc Med. 1970; 63(1):11-5.

PMID: 4317356 PMC: 1810900.