Article: Changes in the drug resistance of Staphylococcus aureus in a non-hospital population during a 20-year period

The antibiotic resistance of Staphylococcus aureus isolated in Bristol from primary skin sepsis and nasal carriers outside hospital was recorded between 1949 and 1969. The proportion of penicillinase-forming strains rose to about 60% but resistance to other antibiotics remained un-common except for a peak about 1957, due to the spread of multiresistant phage-type 80 staphylococci. Reasons are discussed for the failure of other multiresistant staphylococci to increase outside hospital.Recently isolated strains from inside and outside hospital were tested with sulphonamide and trimethoprim. All were sensitive to trimethoprim but 5% of non-hospital strains and 40% of hospital strains were resistant to sulphonamide. It is suggested that sulphonamide-resistant staphylococcal infections should not be treated with sulphonamide-trimethoprim mixtures because of the risk of breeding trimethoprim-resistant strains.

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References

1.

ANNEAR D . The effect of temperature on resistance of Staphylococcus aureus to methicillin and some other antibioics. Med J Aust. 1968; 1(11):444-6. View

2.

Price D, OGRADY F, Shooter R, Weaver P . Trial of phenoxymethylpenicillin, phenethicillin, and lincomycin in treatment of staphylococcal sepsis in a casualty department. Br Med J. 1968; 3(5615):407-9. PMC: 1986303. DOI: 10.1136/bmj.3.5615.407. View

3.

Fallon R . Antibiotics in the treatment of E.N.T. infections. Br Med J. 1968; 4(5622):55. PMC: 1912047. DOI: 10.1136/bmj.4.5622.55-c. View

4.

Churcher G . A screening test for the detection of methicillin-resistant staphylococci. J Clin Pathol. 1968; 21(2):213-7. PMC: 473740. DOI: 10.1136/jcp.21.2.213. View

5.

JESSEN O, ROSENDAL K, Bulow P, Faber V, ERIKSEN K . Changing staphylococci and staphylococcal infections. A ten-year study of bacteria and cases of bacteremia. N Engl J Med. 1969; 281(12):627-35. DOI: 10.1056/NEJM196909182811201. View

6.

Lacey R, Alder V, Gillespie W . The surivival of Staphylococcus aureus on human skin. An investigation using mixed cultures. Br J Exp Pathol. 1970; 51(3):305-13. PMC: 2072282. View

7.

CLARKE S, DALGLEISH P, Gillespie W . Hospital cross-infections with staphylococci resistant to several antibiotics. Lancet. 1952; 1(6719):1132-5. DOI: 10.1016/s0140-6736(52)91038-6. View

8.

Gillespie W, Alder V . Control of an outbreak of staphylococcal infection in a hospital. Lancet. 1957; 272(6969):632-4. DOI: 10.1016/s0140-6736(57)91091-7. View

9.

Thompson M, Gillespie W . Nasal carriage of Staphylococcus aureus by nurses. J Pathol Bacteriol. 1958; 75(2):351-5. DOI: 10.1002/path.1700750213. View

10.

Corner B, CROWTHER S, EADES S . Control of staphylococcal infection in a maternity hospital; clinical survey of the prophylactic use of hexachlorophane. Br Med J. 1960; 1(5190):1927-9. PMC: 1968093. DOI: 10.1136/bmj.1.5190.1927. View

11.

Richmond M, PARKER M, Jevons M, John M . HIGH PENICILLINASE PRODUCTION CORRELATED WITH MULTIPLE ANTIBIOTIC RESISTANCE IN STAPHYLOCOCCUS AUREUS. Lancet. 1964; 1(7328):293-6. DOI: 10.1016/s0140-6736(64)92407-9. View

Changes in the Drug Resistance of Staphylococcus Aureus in a Non-hospital Population During a 20-year Period