Australia Antigen and Liver Function Tests Following Infectious Hepatitis. A Study of 111 Patients in Quest of Aids in Blood Donor Screening

Overview

Journal Calif Med

Date 1971 Apr 1

PMID 5551301

Authors

D G Johnston

N Powell Jr

G Gitnick

Affiliations

Soon will be listed here.

Abstract

An epidemic of infectious hepatitis involving 99 patients and employees of a state mental hospital revealed Australia antigen Au(1) to be absent from the blood of all but one of the subjects when tested at six weeks, three months, nine months and 12 to 18 months after onset of jaundice. The single patient with Au(1) at 12 months had no enzyme abnormality to indicate residual liver disease. If Au(1) is the virus of hepatitis these data would support the concept that persistent or long standing viremia is not a feature of epidemic hepatitis. Moreover, results of this study suggest that the Au(1) test should not be used to establish the absence of a past history of hepatitis in blood donors. These data do not establish the value of the Au(1) test in blood donors with active viremia, but do suggest that of 111 patients with recent hepatitis 1 percent had persistent antigenemia and 4 percent probably had circulating antigen antibody complexes and constituted a potential risk to recipients of their blood. The degree of risk to recipients from transfused blood of post-hepatitis patients without demonstrable Au(1) cannot be assessed.

References

Allen J . The advantages of the single transfusion. Ann Surg. 1966; 164(3):475-81. PMC: 1477287. DOI: 10.1097/00000658-196609000-00010. View

Krugman S, GILES J, Hammond J . Infectious hepatitis. Evidence for two distinctive clinical, epidemiological, and immunological types of infection. JAMA. 1967; 200(5):365-73. DOI: 10.1001/jama.200.5.365. View

Blumberg B, Gerstley B, HUNGERFORD D, London W, Sutnick A . A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis. Ann Intern Med. 1967; 66(5):924-31. DOI: 10.7326/0003-4819-66-5-924. View

Blumberg B, Melartin L, Lechat M, GUINTO R . Association between lepromatous leprosy and Australia antigen. Lancet. 1967; 2(7508):173-6. DOI: 10.1016/s0140-6736(67)90003-7. View

Prince A . Relation of Australia and SH antigens. Lancet. 1968; 2(7565):462-3. DOI: 10.1016/s0140-6736(68)90512-6. View

Sutnick A, London W, Gerstley B, Cronlund M, Blumberg B . Anicteric hepatitis associated with Australia antigen. Occurrence in patients with Down's syndrome. JAMA. 1968; 205(10):670-4. View

Prince A . An antigen detected in the blood during the incubation period of serum hepatitis. Proc Natl Acad Sci U S A. 1968; 60(3):814-21. PMC: 225124. DOI: 10.1073/pnas.60.3.814. View

London W, Sutnick A, Blumberg B . Australia antigen and acute viral hepatitis. Ann Intern Med. 1969; 70(1):55-9. DOI: 10.7326/0003-4819-70-1-55. View

Sutnick A, London W, Blumberg B . Australia antigen and the quest for a hepatitis virus. Am J Dig Dis. 1969; 14(3):189-94. DOI: 10.1007/BF02235880. View

10.

HIRSCHMAN R, Shulman N, Barker L, Smith K . Virus-like particles in sera of patients with infectious and serum hepatitis. JAMA. 1969; 208(9):1667-70. View

11.

Shulman N, Barker L . Virus-like antigen, antibody, and antigen-antibody complexes in hepatitis measured by complement fixation. Science. 1969; 165(3890):304-6. DOI: 10.1126/science.165.3890.304. View

12.

GILES J, McCOLLUM R, Berndtson Jr L, Krugman S . Relation of Australia-SH antigen to the willowbrook MS-2 strain. N Engl J Med. 1969; 281(3):119-22. DOI: 10.1056/NEJM196907172810302. View

13.

Wright R, McCOLLUM R, KLATSKIN G . Australia antigen in acute and chronic liver disease. Lancet. 1969; 2(7612):117-21. DOI: 10.1016/s0140-6736(69)92437-4. View

14.

Gitnick G, Gleich G, SCHOENFIELD L, BAGGENSTOSS A, Sutnick A, Blumberg B . Australia antigen in chronic active liver disease with cirrhosis. Lancet. 1969; 2(7615):285-8. DOI: 10.1016/s0140-6736(69)90052-x. View

15.

Zuckerman A . Viral hepatitis and the Australia-SH antigen. Nature. 1969; 223(5206):569-72. DOI: 10.1038/223569a0. View

16.

London W, Di Figlia M, Sutnick A, Blumberg B . An epidemic of hepatitis in a chronic-hemodialysis unit. Australia antigen and differences in host response. N Engl J Med. 1969; 281(11):571-8. DOI: 10.1056/NEJM196909112811101. View

17.

Boeve N, WINTERSCHEID L, MERENDINO K . Fibrinogen-transmitted hepatitis in the surgical patient. Ann Surg. 1969; 170(5):833-8. PMC: 1387662. DOI: 10.1097/00000658-196911000-00015. View

18.

Walsh J, Purcell R, Morrow A, Chanock R, Schmidt P . Posttransfusion hepatitis after open-heart operations. Incidence after the administration of blood from commercial and volunteer donor populations. JAMA. 1970; 211(2):261-5. DOI: 10.1001/jama.211.2.261. View

19.

Blumberg B, Melartin L . Australia antigen and hepatitis. Studies in asymptomatic people and lepromatous leprosy patient. Arch Intern Med. 1970; 125(2):287-92. DOI: 10.1001/archinte.125.2.287. View

20.

Shulman N, HIRSCHMAN R, Barker L . Viral hepatitis. Ann Intern Med. 1970; 72(2):257-69. DOI: 10.7326/0003-4819-72-2-257. View