Insulin and Microtubules in Rat Adipocytes

Overview

Journal Science

Specialty Science

Date 1971 Apr 16

PMID 5548707

Citations 7

Authors

D Soifer

T Braun

O HECHTER

Affiliations

Soon will be listed here.

Abstract

Insulin appears to promote microtubule assemblty in rat adipocytes. Neithler oxytocin nor high concentrations of glucose has this effect. Colchicine inihibits stimulation by insulin of lipid and glycogen synthesis without influencing stimulation by insulin of glucose oxidation. The anabolic effects of oxytocin or high concentrations of glucose are not inhibited by colchicine. The "directive effect" of insulin may involve microtubules.

Citing Articles

Microtubules in insulin action: what's on the tube?.

Batty S, Langlais P Trends Endocrinol Metab. 2021; 32(10):776-789.

PMID: 34462181 PMC: 8446328. DOI: 10.1016/j.tem.2021.07.008.

Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake.

Fletcher L, Welsh G, Oatey P, Tavare J Biochem J. 2000; 352 Pt 2:267-76.

PMID: 11085918 PMC: 1221456.

Stimulation by insulin of cell elongation and microtubule assembly in embryonic chick-lens epithelia.

Piatigorsky J, Rothschild S, Wollberg M Proc Natl Acad Sci U S A. 1973; 70(4):1195-8.

PMID: 4515617 PMC: 433456. DOI: 10.1073/pnas.70.4.1195.

Effects of cytochalasin B, colchicine and vincristine on the metabolism of isolated fat-cells.

Loten E, Jeanrenaud B Biochem J. 1974; 140(2):185-92.

PMID: 4455189 PMC: 1167990. DOI: 10.1042/bj1400185.

Fat mobilization and ultrastructural changes in the peritoneal fat body of the lizard, Klauberina riversiana, in response to long photoperiod and exogenase estrone or progesterone.

LAPOINTE J, Rodriguez E Cell Tissue Res. 1974; 155(2):181-92.

PMID: 4442112 DOI: 10.1007/BF00221352.