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Design, Synthesis and Characterisation of a 34-residue Polypeptide That Interacts with Nucleic Acids

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Journal Nature
Specialty Science
Date 1979 Oct 25
PMID 551285
Citations 16
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Abstract

Based on secondary structure prediction rules and model building a neutral artificial 34-residue polypeptide with potential nucleic acid-binding activity was synthesised. This peptide and its covalent dimer showed strong interaction with cytidine phosphates and single-stranded DNA. The dimer had considerable ribonuclease activity with high preference for cleavage at the 3'-end of C.

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